Endocrine Abstracts

Data on coexisting Graves’ disease (GD), systemic lupus erythematosus (SLE), and hypoparathyroidism (hypop) are limited. Scanty case reports have described hypoparathyr or hypothyroidism (late complication) following external irradiation to the neck. The thyroid and parathyroid glands may be sensitive to the immunologic or irradiation damage.A 34-year old AA woman presented with tetanic-like cramps, easy skin bruising, fatigue, weight gain, nocturia...

Context: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in the autoimmune regulator (AIRE) gene and is characterised by the presence of chronic mucocutaneous candidiasis, hypoparathyroidism and Addison’s disease. Patients typically display organ-specific autoantibodies which correlate with a particular clinical manifestation. Previous studies have identified the parathyroid-expressed calcium-sensing receptor (CaSR) as an aut...